Job ID 12524 Location Case Main Campus Full/Part Time Full-Time Regular/Temporary Regular Job Description POSITION OBJECTIVE Working with a high degree of independence and under general direction, the Research Assistant 4 will coordinate major activities of laboratory and research staff in medical and related technical areas. The research assistant will plan and perform complex protocols for the evaluation of biological rhythms in mice. These protocols include, but are not limited to, surgical implantation of wireless telemetry probes to measure EEG, EMG, ECG, glucose, temperature, activity, and pressure, microdissection, working with sensitive circadian monitoring equipment, and measurement of protein and nucleic acid. The research assistant is expected to provide high-level input to the principal investigator regarding planning, execution, and development of research projects, assist in development of laboratory procedures. Administratively, the research assistant will coordinate and manage all major activities in the laboratory, manage safety protocols, and mentor junior staff and students. Additionally, the research assistant will co-author and present major findings from the laboratory. This position will work with animals. ESSENTIAL FUNCTIONS Provide input and recommendations to the principal investigator regarding significant developments in research projects and execution of experimental protocols. Assist in experimental planning, frequently communicating data and research project updates. Meet to discuss project implementation with the principal investigator on a weekly basis, and participate in monthly meetings with the Circadian Rhythm Team. (24%) Coordinate major activities of laboratory/research. Plan and execute major experiments, delegate and oversee certain aspects of experimental protocols, manage data and equipment, and perform complex data analyses. Perform small animal surgeries including anesthetizing mice, monitoring for adverse effects, implanting telemetry devices, and eventual euthanasia of the mice. Conduct tissue harvest and coordinate with the histology core as required. (29%) Co-author research projects and major findings of the laboratory with the principal investigator. Utilize understanding of circadian rhythm software packages, to assist the principal investigator with data analysis and to present data at conferences. (10%) Perform the most complex quantitative analytical procedures. Perform data analysis including qPCR, various protein analyses, and circadian analysis of mouse parameters including temperature, motor activity, glucose, EEG, EMG, and EKG. (19%) May supervise research assistants and technicians. Responsible for day-to-day supervision of students when rotating through the lab. (6%) Teach or instruct others in research techniques. Alongside the principal investigator, teach students and junior staff research techniques used in the lab including implant surgeries, recharging devices, and maintaining the circadian monitoring systems. (6%) Assist in developing procedures for safe animal experiments and surgeries, coordinate information with other staff and investigators as needed. Help with the renewal and amendments to IACUC protocols, and coordinate use of shared circadian monitoring equipment as needed. (6%) NONESSENTIAL FUNCTIONS Perform other duties as assigned, including management of service contracts, light equipment upkeep, and management of safety protocols, standard operating procedures handbooks, and SDS books. ( CONTACTS Department: Daily contact with supervisor to discuss research and maintain workflow. University: Occasional contact with other departments to share information. External: Occasional contact with vendors to exchange information. Students: Contact with student employees to exchange information. SUPERVISORY RESPONS