Life Science Research Professional 1

School of Medicine, Stanford, California, United States

Research

Post Date Mar 27, 2024

Requisition # 102690

We are seeking an exceptional, highly motivated and collaborative Life Science Research Professional to join the Prolo Lab in the Department of Neurosurgery, Stanford University School of Medicine. The successful candidate will work independently and with other team members on projects related to understanding the molecular and cellular mechanisms underlying pediatric high-grade glioma growth and invasion in order to find new therapeutic targets.

The ideal candidate will be highly self-motivated and will have an outstanding track-record of innovation and success in previous research experiences. The candidate will work independently and collaboratively to design and conduct laboratory experiments in patient derived tumor models and in rodent xenograft models. The candidate will have familiarity with the following or be willing to learn the following: CRISPR/Cas9 technology, metabolomics, cell culture, DNA recombinant methods and plasmid cloning, imaging and quantitative analyses, biochemistry including Western blotting and protein purification, manuscript preparation and grant preparation.

Main Duties:

• Perform experiments (e.g., primary tumor modeling, cell culture, ICC, IHC, Western blotting, confocal microscopy), maintain detailed records of experiments (related to cell lines and animal surgeries), analyze and interpret research data using GraphPad Prism, ImageJ, and MATLAB. Perform experiments related to other projects in the lab or with collaborators as needed.

• Review literature related to current projects (e.g., pediatric brain tumor invasion, CRISPR/Cas9 screens) for applying new/updated approaches and findings.

• Contribute to publication of experiment results, which include the preparation of manuscripts, protocols, conference presentations, and research proposals at the scientific and clinical society of neurosurgery and neuro-oncology.

• Contribute to the development of bioinformatics workflows or application of existing pipelines for analysis of transcriptomic and proteomic data from pediatric brain tumor patients.

• Make efforts to gain expert-level of scientific knowledge and experimental skills related to multiple research projects mentioned above.

Duties include*:

• Plan approach to experiments in support of research projects in lab and/or field based on knowledge of scientific theory.

• Independently conduct experiments; maintain detailed records of experiments and outcomes.

• Apply the theories and methods of a life science discipline to interpret and perform analyses of experiment results; offer suggestions regarding modifications to procedures and protocols in collaboration with senior researcher.

• Review literature on an ongoing basis to remain current with new procedures and apply learnings to related research.

• Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.

• Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed.

• Assist with orientation and training of new staff or students on lab procedures or techniques.

*-Other duties may be assigned.

This will be for fully on-site work.

Minimum Requirements:

• Bachelor's degree in Cancer Biology, Biology, Biochemistry, Neurobiology, Bioengineering, or related scientific field with two years of relevant research experience.

• Comprehensive understanding of scientific principles.

• Strong analytical skills.

• Technically rigorous.

• Ability to keep an organized lab notebook.

• Integrity and attention to details.

• Excellent interpersonal and communication skills.

• Be able to work both collaboratively and independently.

Desired Qualifications:

• Strong experience in tumor modeling.

• Rat/mouse handling.

• Hands-on experience in biological/biochemical assays (e.g., qPCR, ELISA, WB, FACS, etc).

• Experience in prep of histology samples (brain tissues are preferred).

• Experience in confocal microscopy.

• Experience in primary cell cultures.

EDUCATION & EXPERIENCE (REQUIRED):

Bachelor's degree in related scientific field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

• General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.

• Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.

• Ability to maintain detailed records of experiments and outcomes.

• General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications

• Ability to work under deadlines with general guidance.

• Excellent organizational skills and demonstrated ability to accurately complete detailed work.

PHYSICAL REQUIREMENTS*:

• Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.

• Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.

• Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.

• Must have correctible vision to perform duties of the job.

• Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.

• Ability to lift heavy objects weighing up to 50 pounds.

• Ability to work in a dusty, dirty, and odorous environment.

• Position may require repetitive motion.

*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

WORKING CONDITIONS:

• May require working in close proximity to blood borne pathogens.

• May require work in an environment where animals are used for teaching and research.

• Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.

• Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.

• May require extended or unusual work hours based on research requirements and business needs.

WORK STANDARDS:

• Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.

• Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.

• Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University’s Administrative Guide,http://adminguide.stanford.edu.

The expected pay range for this position is $26.44 to $36.54 per hour.

Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.

At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford’s extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.

Consistent with its obligations under the law, the University will provide reasonable accommodations to applicants and employees with disabilities. Applicants requiring a reasonable accommodation for any part of the application or hiring process should contact Stanford University Human Resources by submitting acontact form.

Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.

Additional Information

• Schedule: Full-time

• Job Code: 4943

• Employee Status: Regular

• Grade: E

• Requisition ID: 102690

• Work Arrangement : On Site